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Nikki van Leeuwen

Scientific Researcher
Nikki van Leeuwen

Research group

Medical Decision-making
Nikki van Leeuwen

I work as a postdoctoral researcher in the Medical Decision Making group at the department of Public Health. I have a background in Health Sciences (BSc) and Clinical Epidemiology (MSc). I conducted my PhD thesis at the department of Public Health with the title: Design and analysis of randomized and non-randomized studies: improving validity and reliability.

My main research interests are: causal inference in observational data, measuring quality of care and the evaluation of value-based healthcare. Currently I supervise 8 PhD students.

Erasmus Medical Center Rotterdam
Internal post address Na-2401
P.O. Box 2040
3000 CA Rotterdam

Visitor address:

Erasmus MC
Room no.: NA-23 or 24th floor
Dr. Molewaterplein 40
3015 GD Rotterdam


Action Line leader Outcome-based health care – Smarter Choices for Better Health 2.0

Quality and effectiveness of oncology care – Collaboration with Netherlands Comprehensive Cancer Organisation (INKL)


  • PERFEQTOS – Performance feedback on quality of care in hospitals performing thrombectomy for ischemic stroke, a cluster-randomized trial
  • UNITE – Uitkomstgericht organiseren en betalen van regionaal georganiseerde zorg voor herseninfarct patiënten
  • NFU Review Value Based Integrated Care
  • IBD Value study – A value-based care pathway for the treatment of IBD with biologics: a multicentre longitudinal pre-post study


Course coordinator Value-Based Health Care (5EC) – ESHPM

Lecture “Quality of Care” – Medicine BSc & Clinical Technology BSc

Invited lecturer at the Erasmus Value-Based Health Care Summer course on Pitfalls of benchmarking

Community projects – Medicine BSc – Supervisor of project group with 5-6 students

Publications list

Most relevant publications

Regression discontinuity was a valid design for dichotomous outcomes in three randomized trials

Nikki van Leeuwen, Hester F Lingsma, Simon P Mooijaart, Daan Nieboer, Stella Trompet, Ewout W Steyerberg

J Clin Epidemiol

Regression Discontinuity Design: Simulation and Application in Two Cardiovascular Trials with Continuous Outcomes

Nikki van Leeuwen, Hester F Lingsma, Anton J M de Craen, Daan Nieboer, Simon P Mooijaart, Edo Richard, Ewout W Steyerberg


Improving quality of stroke care through benchmarking center performance: why focusing on outcomes is not enough

Marzyeh Amini, Nikki van Leeuwen, Frank Eijkenaar, Maxim J H L Mulder, Wouter Schonewille, Geert Lycklama À Nijeholt, Wouter H Hinsenveld, Robert-Jan B Goldhoorn, Pieter Jan van Doormaal, Sjoerd Jenniskens, Jan Hazelzet, Diederik W J Dippel, Bob Roozenbeek, Hester F Lingsma, MR CLEAN Registry Investigators

BMC Health Serv Res

Ordinal outcome analysis improves the detection of between-hospital differences in outcome

Iris E Ceyisakar, Nikki van Leeuwen, Diederik WJ Dippel, Ewout W Steyerberg, Hester F Lingsma

BMC Med Res Methodol

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